ncku-talk2013-03-21

NCTS(South)/ NCKU Math Colloquium

DATE 2013-03-21　15:00-16:00

PLACE R204, 2F, NCTS, NCKU

SPEAKER Mr. Dean Chou (周鼎贏先生)（University of Oxford）

TITLE Water Transport in the Brain: Cerebrospinal Fluid, Capillaries and Glial Cells

ABSTRACT Cerebrospinal fluid (CSF) is recognized to play a dominant role in the brain environment and central nervous system (CNS). At the microscopic level, glial cells and water channel proteins (WCPs), also known as aquaporins (AQPs), are believed to be an important factor in regulating CSF in the cerebral environment and CNS. Furthermore, such elements are postulated to associate with numerous cerebral pathologies, such as brain oedema, brain trauma, brain tumors, stroke, hydrocephalus, migraines, as well as other neurological pathologies, such as multiple sclerosis (MS) and neuromyelitis optica (NMO).
The novelty of the present research is to demonstrate such pathophysiological phenomena via a multiscale physical model incorporating mechanisms across all scales, including the AQP effects. The physical multiscale model proposed can explore the macroscopic relationship between CSF and glial cells via the microscopic incorporation of AQPs. This study aims to make a tangible contribution to the understanding of cerebral or neurological pathologies, but also to pharmaceuticals development.

NCTS(South)/ NCKU Math Colloquium

DATE	2013-03-21　15:00-16:00

PLACE	R204, 2F, NCTS, NCKU

SPEAKER	Mr. Dean Chou (周鼎贏先生)（University of Oxford）

TITLE	Water Transport in the Brain: Cerebrospinal Fluid, Capillaries and Glial Cells

ABSTRACT	Cerebrospinal fluid (CSF) is recognized to play a dominant role in the brain environment and central nervous system (CNS). At the microscopic level, glial cells and water channel proteins (WCPs), also known as aquaporins (AQPs), are believed to be an important factor in regulating CSF in the cerebral environment and CNS. Furthermore, such elements are postulated to associate with numerous cerebral pathologies, such as brain oedema, brain trauma, brain tumors, stroke, hydrocephalus, migraines, as well as other neurological pathologies, such as multiple sclerosis (MS) and neuromyelitis optica (NMO). The novelty of the present research is to demonstrate such pathophysiological phenomena via a multiscale physical model incorporating mechanisms across all scales, including the AQP effects. The physical multiscale model proposed can explore the macroscopic relationship between CSF and glial cells via the microscopic incorporation of AQPs. This study aims to make a tangible contribution to the understanding of cerebral or neurological pathologies, but also to pharmaceuticals development.